Thymosin Beta-4 (Tβ4) is a naturally occurring 43-amino-acid peptide found in a variety of human tissues and biological fluids. It has been extensively studied for its interaction with actin and its involvement in cellular processes including cell migration, cytoskeletal organization, angiogenic signaling, and tissue-related biological pathways.

Preclinical and clinical research has investigated Thymosin Beta-4 in areas including cellular repair mechanisms, vascular biology, inflammation-related signaling, and ophthalmic research. The full-length peptide should be distinguished from TB-500, which is a synthetic fragment corresponding to residues 17–23 of Thymosin Beta-4.

Thymosin Beta-4 remains an investigational research compound and should not be represented as an approved therapeutic product. Research findings involving the full-length peptide should not automatically be applied to TB-500 or other related fragments.