Glutathione (GSH) is a tripeptide composed of glutamate, cysteine, and glycine and is one of the major intracellular antioxidants found in mammalian cells. It plays an important role in maintaining cellular redox homeostasis and protecting cellular components from oxidative stress.

Research has examined glutathione in relation to reactive oxygen species, detoxification pathways, protein redox regulation, cellular signaling, mitochondrial function, and DNA-related processes. Glutathione exists primarily in its reduced form (GSH) and can be converted to oxidized glutathione (GSSG) during antioxidant reactions, with cellular enzymes helping maintain the GSH/GSSG redox balance.

Glutathione is an established area of biochemical and cellular research, particularly in studies of oxidative stress, redox metabolism, mitochondrial biology, and cellular defense mechanisms.