GW-501516 10mg/30ml Liquid

Research Overview

GW-501516 is a synthetic, high-affinity agonist of peroxisome proliferator-activated receptor delta, a nuclear receptor that functions as a ligand-activated transcription factor. On activation, PPARδ heterodimerizes with RXR and drives transcription of gene programs governing fatty acid transport, beta-oxidation, and mitochondrial biogenesis, with pronounced activity in skeletal muscle and adipose tissue. This transcriptional profile made the compound a widely cited chemical probe in exercise-physiology and substrate-utilization research. It is important to note that clinical development was discontinued after preclinical toxicology studies identified carcinogenic findings in rodent models; the compound persists in science solely as a research tool and reference agonist. Laboratory applications include nuclear receptor transactivation assays, myotube culture, mitochondrial biogenesis profiling, and gene-expression studies of oxidative metabolism.

Common Research Areas

• PPARδ receptor pharmacology
• Fatty acid oxidation
• Mitochondrial biogenesis
• Skeletal muscle metabolism
• Nuclear receptor signaling
• Exercise physiology models

Key Features

• Presentation: Oral solution (30 mL) at 10 mg/mL
• Category: Weight Management — wholesale supply only
• Minimum order quantity: 10 units per SKU
• Applied in pparδ receptor pharmacology and fatty acid oxidation
• Cold-chain handling: store at 2–8°C, protected from light
• Research Use Only — not for human or animal consumption

Product Information

Category

Weight Management

Format

Oral solution (30 mL)

Strength

10 mg/mL

Minimum Order Quantity

10 units

Wholesale Availability

Wholesale only

Why Researchers Choose This Product

GW-501516 remains one of the best-characterized PPARδ agonists available to researchers, making it a standard reference ligand for transactivation and oxidative-metabolism assays. Laboratories include it precisely because its transcriptional signature is so thoroughly documented in the published literature.

Storage

Store refrigerated at 2–8°C. Protect from heat and light. Keep tightly sealed and avoid repeated temperature cycling. For laboratory research use only.

Frequently Asked Questions

What is GW-501516 10mg/30ml Liquid studied for?

GW-501516 is a selective PPARδ agonist studied for its effects on fatty acid oxidation, mitochondrial gene expression, and substrate utilization in skeletal muscle. It is used strictly as a laboratory reference compound in metabolic and exercise-physiology research models. Following discontinuation of clinical development on toxicology grounds, it persists in science solely as a reference agonist for nuclear receptor transactivation work.

What research applications does GW-501516 10mg/30ml Liquid support?

Reported laboratory applications span pparδ receptor pharmacology, fatty acid oxidation, mitochondrial biogenesis, skeletal muscle metabolism, nuclear receptor signaling, and exercise physiology models. GW-501516 remains one of the best-characterized PPARδ agonists available to researchers, making it a standard reference ligand for transactivation and oxidative-metabolism assays. Laboratories include it precisely because its transcriptional signature is so thoroughly documented in the published literature.

What format, strength, and minimum order apply?

GW-501516 10mg/30ml Liquid is supplied as oral solution (30 ml) at 10 mg/mL. The minimum order quantity is 10 units per SKU, and it is available to wholesale buyers only — laboratories, research organizations, distributors, and qualified commercial accounts.

How should this product be stored and handled?

Store refrigerated at 2–8°C. Protect from heat and light. Keep tightly sealed and avoid repeated temperature cycling. For laboratory research use only.

Is this product suitable for human or animal use?

No. This product is supplied strictly for laboratory and scientific research by qualified professionals. It is not for human or animal consumption, is not intended for human or veterinary use, and is not approved to diagnose, treat, cure, or prevent any disease.

This product is intended exclusively for laboratory research and analytical purposes. NOT FOR HUMAN CONSUMPTION. Not intended to diagnose, treat, cure, or prevent any disease.